The alteration of the lipemia-clearing effect of heparin following the intravenous injection of thorium dioxide (thorotrast).
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The Effectiveness of Colloidal Thorium Dioxide as an Internal Alpha Emitter: A Combined Morphologic and Radioautographic Study ‡
The hazard of ionizing radiation from internally administered colloidal thorium dioxide (Thorotrast) has been a subject of controversy even since this medium was first employed in clinical roentgenology. Reports of neoplasia as well as diffuse hepatic fibrosis occurring in patients following Thorotrast administration have been summarized and evaluated by Thomas et al.7 Although intravenous inje...
متن کاملPrimary liver cell carcinoma 24 years after intravenous injection of thorotrast.
Thorium dioxide, when injected intravenously, is taken up by the reticulo-endothelial system and retained indefinitely, rendering the liver and spleen radio-opaque (Radt, 1930). A 25% colloidal solution of thorium dioxide was marketed under the name of "thorotrast" and used not only for hepatolienography but for retrograde pyelography, bronchography, and angiography generally, not to mention ot...
متن کاملIdentification of thorium dioxide in human liver cells by electron microscopic x-ray microanalysis.
Thirty-two years after injection of thorium dioxide (Thorotrast) for diagnostic x-ray studies in a female patient deposits were found by light microscopy in the liver macrophages (Kupffer cells). They were shown by electron microscopy to be located inside secondary lysosomes, and by autoradiography and x-ray microanalysis they were identified as thorium.
متن کاملThe Inhibition of Lipemia-clearing
It was recently shown in this laboratory (1) that in idiopathic hyperlipemia the elimination of lipids from the blood stream following an intravenous infusion of a fat emulsion is considerably delayed, indicating a defect of the lipemiaclearing mechanism in these patients. It was then found that the clearing activity present in the serum of normal human subjects who have received heparin was in...
متن کاملUptake of Colloidal Thorium Dioxide by Mast Cells
Mast cells from the peritoneal cavity of the rat were obtained at various times following in situ injection of a colloidal thorium dioxide preparation (Thorotrast). They were prepared for electron microscopy by aldehyde fixation, osmium tetroxide postfixation, and embedding in Epon. Thorotrast was rapidly taken up by mast cells through enhanced or newly elicited surface specializations. It was ...
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عنوان ژورنال:
- Circulation research
دوره 1 6 شماره
صفحات -
تاریخ انتشار 1953